What mRNA frameshifting means for therapeutic efficacy
Modified mRNAs have become an important platform for developing vaccines and other new therapeutic approaches. One of the most widely used modifications, N¹-methylpseudouridine (m¹Ψ), can improve protein expression while reducing unwanted immune activation, helping mRNA therapeutics produce useful levels of protein in cells. Can N¹-Methylpseudouridine (m¹Ψ) Affect How mRNA Is Translated? However, recent research has…
mRNA therapeutics and the future of rare disease treatments
Treating the thousands of known rare genetic diseases is still an unmet challenge, with many such diseases still having ‘orphan’ designation meaning that no viable options are available for their treatment. mRNA Therapeutics will likely offer treatment options for some, if not many, of these diseases, but ongoing research is required to bring mRNA-based rare…
AI and the design of mRNA Therapeutics
AI is a useful approach for designing high performing sequences, but its usefulness is enhanced when it is combined with information from mechanistic models.
Welcome to the Jantomarna Blog: Exploring the Future of RNA Therapeutics
We announce the Jantomarna Blog, a forum for discussing the latest developments in mRNA Therapeutics.